In this module you have learned of the importance of the immune system in protecting against disease. For the Module 4 case assignment you will investigate the virus HIV and its effect on the human immune system, as well as important topics in infectious disease in general.

It is estimated that over 34 million people globally are living with HIV/AIDS. (http://www.avert.org) Acqiured immune deficiency syndrome (AIDS) has been described as the most common secondary immune deficiency disease in the world. Infection with the human immune deficiency virus (HIV) has been identified as the cause of AIDS. For the module 4 case assignment prepare a paper addressing the following:

Provide a general discussion of HIV/AIDS. In your paper discuss the structure of HIV and how the viral structure facilitates entry into host cells.  Begin your research in your Introductory Microbiology textbook, using Ch 11:  Microbial Epidemiology, Ch 7:  Viral Effects on Cells, and Ch 17:  Viruses and Prions in A Concise Manual of Pathogenic Microbiology.

1.Discuss the function of HIV protease, integrase, and reverse transcriptase.

2.Explain how this pathogen causes disease in the host.

3.Identify the characteristics of HIV which account for its transmission.  Include the basic epidemiology of this virus and its method of transfer.

1.The normal function of the immune system. Be sure to explain the function of B-lymphocytes, killer T-lymphocytes, helper T-lymphocytes, and macrophages.

2.The function of the complement system.

3.How HIV alters normal function of the immune system.

Note: The assignment will require you to engage in independent research.  Begin by reading through the chapters listed above.

Your assignment is due by the Monday following the end of this Module.  Please upload your case assignment.

Case Assignment Expectations

Length:  Case Assignment Module assignments should be at least 2-4 pages (400-800 words) in length.

References: At least two references should be included from academic sources (e.g. peer-reviewed journal articles).  Required readings are included.  Quoted material should not exceed 10% of the total paper (since the focus of these assignments is critical thinking).  Use your own words and build on the ideas of others.   When material is copied verbatim from external sources, it MUST be enclosed in quotes.  The references should be cited within the text and also listed at the end of the assignment in the References section (preferably in APA format).  

Organization: Subheadings should be used to organize your paper according to question

Format: APA format is recommended (but not required) for this assignment.  See Syllabus page for more information on APA format.

Grammar and Spelling: While no points are deducted, assignments are expected to adhere to standards guidelines of grammar, spelling, punctuation, and sentence syntax.  Points may be deducted if grammar and spelling impact clarity.

The following items will be assessed in particular:

•Relevance (e.g. all content is connected to the question)

•Precision (e.g. specific question is addressed.  Statements, facts, and statistics are specific and accurate).

•Depth of discussion (e.g. present and integrate points that lead to deeper issues)

•Breadth (e.g. multiple perspectives and references, multiple issues/factors considered)

•Evidence (e.g. points are well-supported with facts, statistics and references)

•Logic (e.g. presented discussion makes sense, conclusions are logically supported by premises, statements, or factual information)

•Clarity (e.g. writing is concise, understandable, and contains sufficient detail or examples)

•Objectivity (e.g. avoid use of first person and subjective bias)

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